Oncology Journal of India

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Aim of the Study: The aim of this study is to evaluate the demographic and clinicopathological profile of the patients with gallbladder cancer (GBC). Materials and Methods: A total of 68 diagnosed cases of GBC were taken in the study during the study period from January 2016 to December 2017. A detail questionnaire was filled through the counseling to take demographic profile including socioeconomic status, nonclinical characteristics, dietary, and other risk factors apart from clinicopathological profile of patients. Results: We found most of the patients were females with median age 51.8 years. More than half of them were postmenopausal (56.60%), and high parity was seen in 39.62% of females. Obesity was associated factor mainly in females (28/53), and none of the males were obese. Nearly 83.82% (57/68) of patients had advanced stage disease, with metastatic disease in 72.06% (49/68) patients. Majority of the patients had at least two sites of metastasis (73.47%), with liver (57.14%), omentum (40.82%), and nonregional lymph nodes (53.06%) being common sites of dissemination. Bony metastasis, being rare in literature, was found in 6 (12.24%) of patients, most of them developed it later during the disease course. Conclusion: Majority of the patients was female within the age group of 41–60 years, associated with gallstones and had advanced disease. We did not find greater impact of diet on the incidence as vegans and nonvegans were almost equally divided in our study. A high index of suspicion and health education seems to be the only answers available for early detection and improvement of survival.

Hand pain is a common presenting symptom in orthopedic, but digital pain due to glomus tumor is a rare entity. It is a benign vascular neoplasm arising from glomus body with subungual space of nail plate of the hand being the common location. Bluish- or pinkish-red discoloration of the nail plate with classical triad of localized tenderness, severe pain, and cold sensitivity are the common presentations of the glomus tumor. Treatment is purely surgical, i.e., complete surgical excision with dramatic results. We report three cases of subungual glomus tumor in the hand, and all the cases underwent complete excision of the tumor followed by complete relief of the symptoms.

Pleomorphic adenoma is a benign mixed salivary gland tumor and consists of a combination of epithelial and mesenchymal elements. The parotid and other major salivary glands are the common locations for it. Pleomorphic adenoma less frequently originates from minor salivary glands with a malignant potential in most of the cases. The present case is a pleomorphic adenoma of the minor salivary gland of soft palate in a 72-year-old male, and the tumor is large, well circumscribed, firm but still benign in nature and needs reporting.

Testicular metastasis from a solid malignancy of the distant organ is a rare entity and prostate, gastrointestinal tract, lungs, skin, and kidneys are the common primaries. Gastric carcinoma with testicular metastasis is an extremely rare entity with only few cases reported in the literature. Most of the testicular metastases are unilateral. Synchronous bilateral testicular metastasis is an extremely rare situation in gastric primary. We report a first case of synchronous bilateral testicular metastasis in a treated case of gastric carcinoma in India.

Serial spectral domain optical coherence tomography (SD-OCT) images can be applied to monitor the effectiveness of systemic treatment in choroidal metastasis. Besides, it can be used as a guide to shifting to alternate therapy in nonresponding cases. SD-OCT was performed in a patient of primary adenocarcinoma of the lung with choroidal metastasis in the right eye. SD-OCT revealed neurosensory detachment overlying metastasis and involving macula. The patient was started on chemotherapy and external beam radiotherapy. After treatment completion, neurosensory detachment resolved completely with the regaining of normal foveal contour and improvement in visual acuity.

Coagulopathy is a complex finding in acute promyelocytic leukemia (APL), and it may occur due to interplay of the various factors. Neurological manifestations are rare as the initial presentation in APL. This case illustrates status epilepticus as the initial presentation in this disease. Atypical cells on peripheral smear led to the diagnosis of leukemia. This report demonstrates that the patient of APL can present as status epilepticus.

Online since 19^th May, 2017