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Year : 2021  |  Volume : 5  |  Issue : 1  |  Page : 8-12

The utility of screening ultrasound in early diagnosis of gall bladder cancer among high-risk population

1 Department of Medicine, Army Hospital Research and Referral, New Delhi, India
2 Department of Oncology, Army Hospital Research and Referral, New Delhi, India
3 Department of GI Surgery, Army Hospital Research and Referral, New Delhi, India
4 Department of Oncosurgery, Army Hospital Research and Referral, New Delhi, India
5 Department of Radiodiagnosis, Army Command Hospital, Lucknow, Uttar Pradesh, India
6 Department of Psychology, Christ College, Bangalore, India

Correspondence Address:
Ravi K Anadure
Department of Medicine, Army Hospital Research and Referral, New Delhi - 110 010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/oji.oji_51_20

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Background: Screening has led to reduction in mortality for cancers of the cervix, prostate, and colon. Advanced gall bladder carcinoma (GBC) have a poor prognosis, compared to early-stage GBC. The aim of this study was early detection of GBC by ultrasound screening, in a high-risk population. Data were analyzed to look at the impact of screening on staging, operability, and survival. Materials and Methods: In this prospective study spanning 4 years, 978 high-risk individuals as per defined criteria, were screened by ultrasound of the abdomen. The clinical profile of patients with screened GBC (S-GBC) and clinically evident GBC (C-GBC) was studied in terms of stage of detection, operability, and median overall survival (mOS). Results: Six cases of GBC were detected as S-GBC. These were compared with a control population of 119 GBC cases presenting to the cancer outpatient department (C-GBC) in the same period. It was found that S-GBC patients compared to C-GBC, had early stages of diagnosis (P = 0.001) and all underwent curative radical cholecystectomy compared to only 18.8% in C-GBC cases (P = 0.004). At 2 years follow-up, mOS was not reached for S-GBC patients as all patients were alive, compared to 9 months mOS in C-GBC cases (P < 0.05). Conclusions: Screening for GBC leads to the detection of GBC in early stages, ensures surgical resection, and significantly improves mOS. Ultrasound screening in high-risk population is recommended to improve the poor prognosis of GBC.

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