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   Table of Contents - Current issue
Coverpage
April-June 2018
Volume 2 | Issue 2
Page Nos. 23-43

Online since Thursday, June 21, 2018

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EDITORIAL  

Screening for early detection of cancer – Hope for cure p. 23
Tapan Kumar Sahoo
DOI:10.4103/oji.oji_19_18  
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ORIGINAL ARTICLE Top

Cytological pattern of papanicolaou smears and detection of cervical cancers: An experience from a tertiary care center of eastern zone of India p. 25
Debasmita Das, Asaranti Kar, Shreya Rath, Subrat Kumar Baliarsingh, Dibyajyoti Prusty, Akhyaya Kumar Dash
DOI:10.4103/oji.oji_15_18  
Aim of the Study: The present study attempts to explore various types of lesion of the uterine cervix and to find target age groups in which screening efforts can be concentrated for early detection of cervical cancers. Materials and Methods: The study was carried out at a tertiary care institute during the period from May 2016 to December 2017. All the previously conducted cervical Papanicolaou (Pap) smears were analyzed and reported as per the 2001 Bethesda system. The data were noted in a structured pro forma and evaluated. Results: A total of 5025 Pap smears were examined. Maximum number of patients was in the age group of 31–40 years (33.25%). Out of 5025 pap smears, 6.60% (332) of cases were found to be unsatisfactory or inadequate samples, 90.97% (4571) cases were reported as negative for intraepithelial lesion or malignancy, and 2.43% (122) cases had epithelial cell abnormality (ECA). Premalignant lesions such as: atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL) and atypical squamous cells-cannot exclude HSIL (ASCH), and malignant lesions such as squamous cell carcinoma and adenocarcinoma were reported under the ECA positive cases. Majority of premaligant lesions found in the age group of 41–50 years and constitute 44.64% (25/56). Whereas, majority of frank malignancy cases found in the age group of 51–60 and >60 years constituting 43.94% and 37.88%, respectively. Among all the ECA positive cases, 54.10% of cases found to be with malignancies. Conclusion: Proper implementation of Pap smear screening examination can decrease the incidence of cancer cervix along with its downstaging by early detection of precancerous lesions.
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CASE REPORTS Top

Giant liposarcoma of the anterior chest wall p. 29
Sanjoy Panda, Krupasindhu Panda, Sasmita Panda
DOI:10.4103/oji.oji_10_18  
Liposarcoma is a malignant tumor of the adipose tissue and is primarily a tumor of adults above the age group of 50 years. It may occur anywhere in the body. However, the most common sites are thigh and retroperitoneum. Liposarcoma with the chest wall primary is a rare entity with only few cases reported. We report a case of well-differentiated liposarcoma of the anterior chest wall in a 75-year-old male with a presentation of large growth extending to the anterior neck and successfully operated.
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Carcinoma of prostate with endobronchial and mediastinal lymph node metastasis p. 32
KO Rohit, K Praveen Valsalan, Jacob Baby, Nita John, Elizabeth Sunila, Mitchelle Lolly
DOI:10.4103/oji.oji_11_18  
Endobronchial malignancies are usually associated with bronchogenic carcinoma. About 1.1% of cases may be due to extrapulmonary source of metastasis. Only few case reports have mentioned about the carcinoma of prostate with mediastinal lymph node and endobronchial metastasis. Here, we report such a case where endobronchial lesions were removed bronchoscopically and the patient improved symptomatically. Biopsy showed the metastatic adenocarcinoma and immunohistochemistry was positive for prostate-specific antigen.
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Acral metastasis in carcinoma of buccal mucosa: An unusual presentation p. 35
Sugyan Nandan Mohanty, Dipti Rani Samanta, Ajitesh Avinash, Surendra Nath Senapati
DOI:10.4103/oji.oji_13_18  
Acral metastasis is rare in incidence with poor prognosis due to presence of widespread metastases during presentation. Lung is the most common primary for acral metastases followed by breast and kidney. Acrometastasis with head and neck primary is an extremely rare situation with only few cases reported in the literature. Here, we present a case of acral metastases in a 40-year-old male. The patient was previously diagnosed as a case of squamous cell carcinoma of gingivobuccal sulcus on the left side, and for which, he had undergone radical surgery followed by adjuvant concurrent chemoradiation 6 months back. The patient had local recurrence with multiple metastatic pleural nodules during diagnosis of acral metastasis. The patient was treated with one cycle of palliative chemotherapy followed by amputation of the metastatic finger. However, after 2 months of treatment, the patient was died due to the disease progression.
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Glioblastoma multiforme in a pediatric child p. 38
Subhasis Mishra, Ashis Patnaik, Saroj Kumar Das Majumdar, Dillip Kumar Parida
DOI:10.4103/oji.oji_14_18  
Glioblastoma multiforme (GBM) is the most aggressive, malignant primary brain tumor with increasing frequency in older age group. The majority of cases occur in the 6th to 8th decade of life, with a male predominance. GBM is unusual in the pediatric age group and accounts for only 3% of all the childhood brain tumors. The treatment of GBM is still challenging in children. We report a case of GBM in an 11-year-old male child located in the right cerebral hemisphere. Right fronto-parietal craniotomy and gross total excision of the tumor were performed successfully.
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Primitive neuroectodermal tumor of kidney and its rare affection for inferior vena cava p. 41
Kalyan Pandey, Bharat Bhusan Satpathy, Mohanlal Khadia, Padmalaya Devi
DOI:10.4103/oji.oji_16_18  
Primitive neuroectodermal tumors (PNETs) are a group of small round cell malignancies of neural crest origin. Renal PNET (rPNET) is a rare entity affecting young adults and children with a poor prognosis, and involvement of inferior vena cava (IVC) is extremely uncommon. Nonspecific clinical features often preclude preoperative diagnosis which ultimately depends on microscopy and immunohistochemistry. The preferred treatment for rPENT is surgical resection associated with chemotherapy and radiotherapy. We report a case of rPNET in a 16-year-old male which was preoperatively thought to be of renal cell carcinoma and underwent radical nephrectomy with IVC venotomy. The case on histopathology study revealed features of malignant small blue round cell neoplasm and further immunohistochemical examination diagnosed the case as rPNET.
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