|Year : 2018 | Volume
| Issue : 2 | Page : 32-34
Carcinoma of prostate with endobronchial and mediastinal lymph node metastasis
KO Rohit1, K Praveen Valsalan1, Jacob Baby1, Nita John2, Elizabeth Sunila1, Mitchelle Lolly1
1 Department of Pulmonology, Aster Medcity, Kochi, Kerala, India
2 Department of Pathology, Aster Medcity, Kochi, Kerala, India
|Date of Web Publication||21-Jun-2018|
Dr. K O Rohit
Department of Pulmonology, Aster Medcity, Kochi - 682 034, Kerala
Source of Support: None, Conflict of Interest: None
Endobronchial malignancies are usually associated with bronchogenic carcinoma. About 1.1% of cases may be due to extrapulmonary source of metastasis. Only few case reports have mentioned about the carcinoma of prostate with mediastinal lymph node and endobronchial metastasis. Here, we report such a case where endobronchial lesions were removed bronchoscopically and the patient improved symptomatically. Biopsy showed the metastatic adenocarcinoma and immunohistochemistry was positive for prostate-specific antigen.
Keywords: Bronchoscopy, carcinoma prostate, endobronchial metastasis, mediastinal lymphadenopathy
|How to cite this article:|
Rohit K O, Valsalan K P, Baby J, John N, Sunila E, Lolly M. Carcinoma of prostate with endobronchial and mediastinal lymph node metastasis. Oncol J India 2018;2:32-4
|How to cite this URL:|
Rohit K O, Valsalan K P, Baby J, John N, Sunila E, Lolly M. Carcinoma of prostate with endobronchial and mediastinal lymph node metastasis. Oncol J India [serial online] 2018 [cited 2019 Aug 20];2:32-4. Available from: http://www.ojionline.org/text.asp?2018/2/2/32/234900
| Introduction|| |
Endobronchial malignant lesions are most commonly associated with primary lung tumor. Even though secondaries can cause endobronchial lesion rarely, prostate cancer causing endobronchial metastasis is extremely rare. The usual pattern of metastasis in carcinoma of prostate is hematogenous and lymphatic spread. Lymphangitic spread is the most common radiographic presentation of lung metastasis in carcinoma of prostate. Here, we report an unusual presentation of prostate malignancy with mediastinal lymph node and endobronchial metastasis.
| Case Report|| |
A 63-year-old male, diabetic, diagnosed to have carcinoma of prostate in 2007, with multiple bones and mediastinal lymph node metastasis, was presented to us with breathlessness for 2 weeks. He was initially been treated with palliative radiotherapy for symptomatic bony metastasis and had received injection leuprolide 22.5 mg at 3-month intervals for 2 years. Later in 2010, he had increased cough and positron-emission tomography (PET) scan showed the multiple bone and mediastinal lymph node metastasis. He received palliative chemotherapy with docetaxel 135 mg for six cycles at 3-week intervals, followed by received abiraterone 1000 mg daily along with injection leuprolide 3.75 mg on a monthly basis for 9 months. He received mediastinal radiation therapy in palliative intent and was currently on palliative chemotherapy with cabazitaxel 43 mg at three weekly intervals (completed first cycle). He started to have breathlessness for the past 15 days. It increased on exertion, lying in supine position, and relieved on lying to the left side. No associated chest pain, cough, or hemoptysis was present. His routine blood evaluations were within normal limits. Noncontrast computed tomography scan of thorax revealed multiple enlarged mediastinal lymph nodes and an endobronchial lesion in left main bronchus [Figure 1].
|Figure 1: Computed tomography mediastinal window with coronal section showing the left main bronchus lesion with subcarinal and hilar lymphadenopathy|
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Bronchoscopy showed the three glistening globular lesions at the anterior end of carina and the left main bronchus opening [Figure 2] with the largest one was measuring 1 cm × 0.8 cm. These were removed in toto using snare and electrocautery. The postprocedure period was uneventful and the patient was discharged.
|Figure 2: Bronchoscopy showing lesions in the left main bronchus near to carina|
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Histopathology showed bronchial tissue lined by metaplastic squamous epithelium with underlying neoplasm composed of cells arranged in nests, cords, and scattered singly separated by fibrous stroma [Figure 3]. The cells had a moderate amount of eosinophilic cytoplasm and moderately pleomorphic vesicular nucleus, some with distinct nucleolus. On immunohistochemical examination, the tumor cells were positive for prostate-specific antigen (PSA) [Figure 4] and negative for TTF1, CK7, CK20, CD56, and CK5/6. Overall features were in favor of metastasis from prostatic carcinoma. He was advised to continue chemotherapy with cabazitaxel.
|Figure 3: Histopathology × 100 magnification showing metaplastic squamous epithelium with underlying nests of neoplastic cells|
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|Figure 4: Immunohistochemistry showing the prostate-specific antigen positivity|
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| Discussion|| |
Extrathoracic malignancies with metastasis to the lung are common finding; however, endobronchial metastasis is rare. Most often endobronchial lesions occur as a part of bronchogenic carcinoma such as small cell and non-small cell lung carcinoma and neuroendocrine tumors. Only 1.1% have an extrapulmonary source of metastasis. The most common extrapulmonary primary being the colorectal, breast, and kidney, followed by others such as stomach, ovary, thyroid, uterus, testis, and prostate.,,
It is difficult to differentiate endobronchial metastasis of extrapulmonary malignancies from bronchogenic carcinoma. The endobronchial metastases have similar clinical and radiological findings but with different treatment and prognosis in comparison to primary lung cancer. However, endobronchial metastases are commonly underestimated by the clinician as bronchoscopy is not routinely performed in the presence of existing malignancy history. The treatment modality of endobronchial metastasis may different basing upon types of histological features of the primary malignancy, biologic behavior, anatomical location, evidence of other metastatic sites, present symptoms, patient performance status, and life expectancy.
There are only few case reports about prostate cancer with endobronchial metastasis.,,,, Marchioni et al. studied endobronchial metastasis in 174 cases, which showed origin from prostate in 4.5% of cases. Most of these cases on bronchoscopy showed visible lesion and biopsy confirmed prostate origin by immunohistochemistry with PSA. Some of the patients presented with symptoms due to airway obstruction. Prostate cancer can metastasize to regional lymph nodes and bones by hemoatogenous or lymphatic spread. Metastases to supradiaphragmatic nodes are rare. However, in advanced stages, prostate malignancy can also manifest as mediastinal adenopathy.,
Our patient was diagnosed to have metastatic adenocarcinoma of prostate in 2007 and was on treatment with multidisciplinary team approaches. Even though PET scan showed the reduction in size of mediastinal lesions following radiation therapy and cabazitaxel, he developed respiratory symptoms due to airway metastasis. Bronchoscopy showed the left main bronchus had multiple glistening endoluminal masses and biopsy, followed by immunohistochemistry positive for PSA confirms endobronchial metastasis with the prostatic primary. PSA positivity is specific for cancer of prostate origin and any tissue positive for this other than prostate is likely its metastasis. Here, an endobronchial lesion caused partial obstruction of large airway and debulking of the tumor was possible with flexible bronchoscopy.
The recommended treatment is androgen suppression and chemotherapy for prostate malignancy with metastasis. However, the patient's respiratory symptoms completely subsided after the bronchoscopic intervention. He was advised to continue chemotherapy with cabazitaxel.
Carcinoma of the prostate with endobronchial metastasis is an unusual presentation. Our report emphasizes the need for multidisciplinary team approach and need for bronchoscopic interventions in such conditions.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2], [Figure 3], [Figure 4]