| CASE REPORT |
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| Year : 2017 | Volume
: 1
| Issue : 1 | Page : 7-9 |
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Clinicopathological contributions at diagnosis of bilineal extramedullary blast proliferation
Sonali Susmita Nayak1, Neeraj Arora2, Mayur Parihar3, Indu Arun4
1 Department of Pathology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh, India
2 Department of Laboratory Medicine and Molecular Genetics, Tata Medical Centre, Kolkata, West Bengal, India
3 Department of Cytogenetics, Tata Medical Centre, Kolkata, West Bengal, India
4 Department of Pathology, Tata Medical Centre, Kolkata, West Bengal, India
Correspondence Address:
Sonali Susmita Nayak
Department of Pathology, Homi Bhabha Cancer Hospital and Research Centre, Visakhapatnam, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/oji.oji_3_17
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Blast phase of chronic myelogenous leukemia (CML) presenting as extramedullary blast proliferation is seen in only 6%–10% of cases. A bilineal blast proliferation of myeloid and T-cell lymphoid lineage is even rarer. These cases usually have various additional cytogenetic clonal abnormalities along with the presence of Philadelphia chromosome (Ph chromosome) or BCR-ABL fusion gene. Considered to be an aggressive hematologic malignancy, it needs prompt initiation of chemotherapy along with Imatinib and stem cell transplant. We report here a case of bilineal extramedullary blast proliferation in a 33-year-old male presenting with an initial diagnosis of CML. Lymphoblastic lymphoma, de novo acute myeloid leukemia are considered as close differentials; absence of proper clinical findings, lack of other components of myeloid differentiation can be potential pitfalls in arriving at a correct diagnosis. |
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